Document Type : Original Research Article


1 Associate Professor, Department of Infectious Diseases, Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

2 Infectious Diseases and Tropical Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran.

3 Resident of General Surgery, Department of General Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran.


Background: The use of novel agents has been considered for management of different diseases. Gastric ulcer is a common disease. This study aimed to evaluate the effects of Menthone, as a novel agent, on gastric ulcers in Indomethacin-induced model rat.  
Materials and Methods: Animals were divided into 3 groups: 1. Control group that received only distilled water; 2. Animals were treated with 40 mg/kg bw omeprazole (Omeprazole); 3. Animals were treated with 40 mg/kg bw Menthone (Menthone). A single dose of indomethacin (30 mg/kg body weight) was administrated to per animal. Gastric secretions and antioxidant parameters were evaluated in the end of trial.    
Results: It was observed that an increased ulcer index, gastric volume, malondialdehyde level and decreased super oxide dismutase and pepsin activity in control group in comparison to other groups (p <0.05). The use of Menthone and Omeprazole could alleviate the effects of indomethacin.   
Conclusion: Menthone may not have positive effects similar to Omeprazole, but it could attenuate effects of indomethacin. We recommend using of Menthone, as an efficient agent, for treatment of gastric ulcer.

Graphical Abstract

The Protective Role of Menthone Against Indomethacin-Induced Gastric Ulcers in Rat Model


Main Subjects

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